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Protection Against Ischemic Injury In preclinical models, ARA-290 protects tissues exposed to: Hypoxia Ischemia-reperfusion injury Oxidative stress This has implications for: Cardiovascular health Kidney protection Neurovascular integrity 4

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Milk Thistle (Silymarin) Silymarin: Supports hepatocyte repair Reduces oxidative damage Improves liver enzyme profiles Curcumin Curcumin reduces: Inflammation Hepatic fat accumulation Oxidative stress Omega-3 Fatty Acids Omega-3s reduce liver fat and improve insulin sensitivity, indirectly lowering GGT

Ca 2+ dynamics were monitored using Cal-520 and confocal microscopy, and insulin secretion was assessed via homogeneous time-resolved fluorescence assay