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Study Design Type: Phase 2, double-blind, randomized, placebo-controlled study Participants: 338 adults (BMI 30 or BMI 27 with a coexisting condition) Groups: Retatrutide 1 mg, 4 mg, 8 mg, 12 mg (different initial doses 2 or 4 mg) and placebo Duration: 48 weeks (plus 4 weeks follow-up) Administration: subcutaneous, 1x weekly Primary endpoint: percentage change in body weight at week 24 Secondary endpoints: change in weight at week 48, 5%, 10%, 15% weight reduction

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doi: 10.1016/j.jhepr.2019.07.002 188 SanyalAJ

PPARs can recognize a large class of endogenous ligands among which some 3 and 6-polyunsaturated fatty acids (PUFAs) and some saturated fatty acids, such as myristic acids