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Description

Proc Natl Acad Sci USA 2012;109:53227

Neuroscience and Behavioral Physiology, 33(8), 853-860

Oxygen plays a pivotal role in radiotherapy by stabilizing DNA damage through the oxygen fixation hypothesis [29, 30]. In the absence of sufficient oxygen, radiation-induced free radicals are rapidly neutralized, preventing the formation of irreparable DNA double-strand breaks [31, 32]