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Efpeglenatide and clinical outcomes with and without concomitant sodium-glucose cotransporter-2 inhibition use in type 2 diabetes: exploratory analysis of the AMPLITUDE-O trial

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If you have known cardiovascular disease or a family history of early heart disease, discuss the TMAO mechanism with your clinician before starting regular supplementation

Frequency Once weekly subcutaneous injection Once daily oral tablet Maintenance dose 2.4mg maintenance dose 25mg maintenance dose Expected weight loss ~14.9% average weight loss (STEP trials) ~13.6-16.6% weight loss (OASIS 4) Availability in Ireland Already available in Ireland Not yet available in Ireland Administration notes More predictable absorption Must be taken fasting (30 min before food) Where Does the World Stand Right Now