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Enhanced survival, reinervation, and functional recovery of intrastriatal dopamine grafts co-transplanted with Schwann cells overexpressing high molecular weight FGF-2 isoforms

It may be appropriate for individuals with weight-loss resistance, insulin resistance, metabolic syndrome, PCOS, elevated cardiometabolic risk, or those who were unable to tolerate full-dose GLP-1 therapy

The interaction energy analysis through Coulombic short-range interaction energy (CIE) and Lennard-Jones short range (LJ-SR) showed that the energy requirement of protein-ligand system of selected compounds, and were aligned more towards the energy requirement of the protein-substrate complex than free protein

This potency difference affects study design decisions around dose selection, endpoint timing, and safety monitoring frequency