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Clinical studies addressing renal endpoints in patients with diabetic and no diabetic kidney diseases are warranted to provide information whether the promising preclinical findings can be translated into clinical benefit for patients with renal diseases

ShHTL1 and ShHTL4 were cloned into pGEX-6P-3 (GE Healthcare) with an N-terminal glutathione S-transferase (GST)-tag and a PreScission protease cleavage site

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