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Arrhythmia-Related Adverse Events Standardized MedDRA Query (SMQ): Arrhythmia-Related Events (Supplementary Appendix, Table S13) Participants with 1 arrhythmia-related event: Placebo: 2/70 (2.9%) 1 mg: 3/69 (4.3%) 4 mg (ID 2 mg): 0/33 (0%) 4 mg (ID 4 mg): 2/33 (6.1%) 8 mg (ID 2 mg): 0/35 (0%) 8 mg (ID 4 mg): 5/35 (14.3%) 12 mg (ID 2 mg): 7/62 (11.3%) Overall: 19 of 337 participants (5.6%) experienced 1 event

The superposition was achieved using equivalent residues from peptide 5 and the GLP-1 peptide

If proper titration starting at the lowest dose with gradual 4-week escalation still produces intolerable GI effects, split dosing may allow continued use of the medication rather than abandoning it entirely

Hair, skin, and other non-GI effects Rapid weight loss from any mechanism can trigger telogen effluvium, a temporary increase in hair shedding that occurs when the body diverts resources away from hair follicle maintenance