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Vegetarianism, female gender and increasing age, but not CNDP1 genotype, are associated with reduced muscle carnosine levels in humans

Some researchers push this to 30 days, but 28 is the conservative guideline supported by most pharmacological references

Consult a healthcare practitioner prior to use if: you are pregnant or breastfeeding, you have a liver or kidney disease, you have a pre-existing seizure disorder or you have been instructed to follow a low protein diet

Although ACC2 does not undergo significant polymerization (presumably due to its mitochondrial association) it is allosterically activated by citrate