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The collagen and elastin stimulation directly addresses the structural degradation underlying wrinkle formation

308 Mechanistically, several posttranslational modifications of proteins, including phosphorylation, ubiquitination, acetylation, O-GlcNAcylation, and methylation, are involved in the regulation of key Hippo/YAP signaling processes by integrating factors and other signaling pathways

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The mechanism involves clearance of senescent Leydig cells that secrete pro-inflammatory SASP factors (IL-1, IL-6, TGF-) which impair testosterone production in neighboring healthy cells