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When estrogen decreases, so do those other neurochemicals, which can cause perimenopausal anxiety. Add to the mix commonly occurring stressful midlife events like financial and relationship pressures, plus career, caretaking, and the countless other energy-draining jobs that so often fall on women in their 40s and 50s (who needs a weighted vest when you carry such a heavy mental load?!)

The most commonly reported side effects were mild and included headache, minor gastrointestinal disturbances (flatulence, mild diarrhea at high doses), upper respiratory symptoms, and mild injection site reactions

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Patients and providers have reported anecdotal improvements in energy levels, reduced fatigue, and enhanced mental clarity or focus following NAD+ therapy