Of the 50 markers investigated, 4, 11 and 25 serum and plasma analytes were significantly different from controls in mild, moderate and severe groups, respectively after false discovery rate (FDR) correction and included several well-defined pro-inflammatory cytokines, including interferon- (IFN), interleukin-6 (IL-6), interleukin-1 (IL-1), interleukin-1RA (IL-1RA), interleukin-8 (IL-8) and 10 kDa interferon gamma-induced protein (IP-10)
Plus, most claimed benefits are based on animal studies, early research, or anecdotal reports, rather than strong human clinical evidence
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In animal models of muscle injury, TB-500-treated tissues demonstrate less fibrosis, better vascularization, and superior biomechanical properties compared to untreated controls
