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Interestingly, environmental factors such as toxins, viruses, and metals, together with SOD-1 mutation, trigger excitotoxicity, mitochondrial dysfunction, oxidative stress, neuroinflammation, and aggregation of abnormal proteins, leading to impairment of axonal transport and neuronal apoptosis (Mori et al., 2019

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The Medical journal of Australia, 185 (4), 223-5 [pubmed] Critical Care Compendium Chris is an Intensivist and ECMO specialist at The Alfred ICU, where he is Deputy Director (Education)