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Since statin-induced cell death exhibited multiple hallmarks of ferroptosis, we next tested whether ferroptosis inhibitors could rescue YR1.7 or MC38 cells from this process

By increasing Ca 2+ influx and consequently insulin granule exocytosis, both pathways work together to promote insulin secretion

Refrigeration at 28C slows these degradation pathways to negligible rates

In iron homeostasis and ferroptosis regulation, Nrf2 maintains the intracellular iron balance by modulating the expression of genes involved in heme synthesis, hemoglobin catabolism, iron storage, and transport, thereby influencing ferroptosis sensitivity (Kerins and Ooi, 2018)