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Degradation versus Inhibition: development of proteolysis-targeting chimeras for overcoming statin-induced compensatory upregulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase

PLoS ONE 7:e34268 Shen W, Hao J, Tian C, Ren J, Yang L, Li X, Luo C, Cotma CW, Liu J (2008) A combination of nutriments improves mitochondrial biogenesis and function in skeletal muscle of type 2 diabetic Goto-Kakizaki rats

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Technologies enabling gene editing or cell-based therapies to enhance performancesuch as follistatin AAV1-FS344, which has documented muscle growth effects in nonhuman primatesfall under this classification