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Additional factors include autonomic dysregulation, small fiber neuropathy, as well genetic and epigenetic predispositions such as polymorphisms in the catechol-O-methyltransferase well as alterations in pain processing pathways (Siracusa et al

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Incretin- and ghrelin-associated functions and metabolic processes were discovered

Chronic hyperglycemia has been shown to lead to lymphatic dysfunction, and insulin resistance may be a risk factor for developing lymphedema ( In addition to weight loss and glucose control, GLP-1 RAs affect both immunologic and inflammatory pathways which may have a direct and positive effect on lymphatic function ( + T cells and differentiation into T-helper 2 (Th2) cells are at the front end of this process ( + lymphocytes ( + T cells, as well as a reduction in the release of IL-5 and IL-13 ( Safety is always of utmost concernan important area of ongoing research is determining the effect of GLP-1 RAs on cancer risk and recurrence