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Recent in vivo electrophysiological recordings in mice indicate that both K and Ca ions play essential roles in the anorexigenic effects of GLP-1 within the arcuate nucleus (ARC)

This suggests that glutathionylation of one of these cysteine residues may be an intermediate toward the formation of the intermolecular disulfide in isoforms possessing both cysteines

Overdosing may cause severe gastrointestinal side effects such as severe nausea, vomiting, hypoglycemia, and hospitalization due to the long half-life of semaglutide

"There are allowances for doctors to make their own decisions backed up by robust evidence to prescribe unapproved products to their patients," the TGA's chief medical adviser Robyn Langham said