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A 2011 systematic review of clinical data suggested that citicoline could hasten the resorption of cerebral edema and improve the recovery of consciousness and neurologic disorders in severe TBI cases (classified by Glasgow Coma Scale [GCS] scores of 8) (5)
& Wikstrm, J
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These findings suggest that endothelial IGF- 1R signaling is essential for regulating skeletal muscle perfusion, and its loss results in diminished vasodilatory capacity, potentially contributing to reduced exercise performance and muscle endurance
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