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GLP-1 expression was downregulated in wild-type Lox5 cells knocked out by FNDC5, and the induced expression of lipolysis and autophagy-related genes and proteins were also inhibited, such as adipose triacylglyceride lipase (ATGL), hormone-sensitive lipase (HSL), and hepatic lipase deficiency gene (LIPC)

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At the same time, the addition of data from other studies, i.e., the further evolution of pharmacogenomics into pharmacoomics, including the pharmacogenomics and pharmacometabolomics of VPA (Figure 7), is now possible and may be required in real clinical practice, especially for studies of drug therapy with VPA drugs for complex diseases with many different underlying issues at the basis of pathophysiological mechanisms, which include, first of all, neurological diseases and mental disorders [131]