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The compound appears to work by increasing intracellular NAD+ levels (through preventing nicotinamide consumption by NNMT), which activates sirtuins and enhances mitochondrial function and fatty acid oxidation, while also promoting a phenomenon called "browning" of white adipose tissue - the transformation of energy-storing white fat cells into metabolically active beige/brown adipocytes that burn fatty acids for thermogenesis rather than storing them

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The cumulative 5-year budget impact demonstrates savings of $14.2 million to the health care system

Concentrations of GHK-Cu in the body decline significantly with age, from approximately 200 ng/mL in young adults to under 80 ng/mL by age 60, making topical replenishment meaningful