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[DOI] [PMC free article] [PubMed] [Google Scholar] 52.Atzori F., Traina T.A., Ionta M.T., Massidda B

M2 macrophages support tumor growth and metastasis by secreting immunosuppressive cytokines, such as IL-10 and TGF-, and promoting angiogenesis and stromal remodeling

Several clinical trials demonstrated that TLK286 was active and safe to use in combination treatment regimens with standard chemotherapeutic agents, including platinums, taxanes, and anthracyclines