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PMID: 3169264 Simon A, Wegrowski Y, Bontemps Y, Maquart FX

This has been confirmed in meta-analyses of tens of clinical trials concerning statins published in the last few years which demonstrated a significant reduction in Alzheimers dementia, vascular dementia, and generally mild cognitive impairment with statin use [376, 377], of which pleiotropic properties of this class of agents are supposed to be the cause

They randomized patients to receive synbiotics (Simbioflora, Farmoquimica, So Paulo, Brazil) or placebo (maltodextrin) 8 days before surgery

Designed individually by treatment response not by a fixed schedule