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They have been found to gradually reduce mitochondrial function in various tissues by preventing mitochondrial replication via inhibition of the polymerase that replicates mtDNA [117,118,119]

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Studies indicate that the glycosylation, SIRT5-mediated deglutarylation and SIRT2-mediated deacetylation all enhance G6PD activity and maintain cellular NADPH homeostasis

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