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Shortly after the original identification, the copper-binding role was established, and the conceptual framing shifted toward GHK as a copper-delivery peptide whose proliferation-supporting activity in the original assays reflected the role of copper in cellular biology rather than a direct growth-factor signaling activity in the classical sense

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The investigators reported improvements in skin density, dermal thickness, laxity (firmness), and reduction of fine lines in the GHK-Cu arm compared with vehicle control over the 12-week treatment period [3]