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Early concentrations of paracetamol in the brain (33) appear to be well-timed with the period of the rising concentration in various brain structures (33) and coincide with the noted brain damage and with the appearance of generalized seizures in the present study

This is evident in IBDs such as Crohns whereby patients have been reported to express receptor variants to IL-23, a cytokine primarily expressed by macrophages and found in elevated abundance in the intestinal mucosa of Crohns patients (Duerr et al

This is why supplementation is often recommended

It has not received FDA approval for therapeutic use in humans