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Methods: retrospective study based on clinical data from the French HAE-nC1-INH registry

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Melatonin may be appropriate for children with: Sleep-onset insomnia (difficulty falling asleep) Delayed sleepphase syndrome (bedtime and wake time delayed by 2 hours) Neurodevelopmental disorders (autism spectrum disorder or ADHD) with documented sleep difficulties For most other children, strong sleep hygiene practices are the first recommendation