(Gupta JK and Qureshi Shaiba Sana, 2015) Alleviates pain in patients with diabetic neuropathy, low back pain and neuralgia
When compared to patients with low MMA and low B12 (MMA low B12 low ), the multivariate-adjusted HRs (95% CIs) for total mortality in the MMA low B12 high, MMA high B12 low , and MMA high B12 high groups were 0.90 (0.731.12), 1.27 (0.951.69), and 1.98 (1.462.69), respectively
According to NICE Clinical Knowledge Summaries, once B12 deficiency is adequately treated and symptoms resolve, routine monitoring of serum B12 levels is generally unnecessary, as clinical response is the primary indicator of treatment effectiveness
Methylcobalamin, the active form of B12, participates in methylation cycles critical for DNA synthesis, myelin formation, and homocysteine metabolism