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BPC 157 was studied almost exclusively by the same Croatian team that created it, doing rat study after rat study, while MK-677 was the domain of the Merck Research Laboratories in New Jersey, whose scientists conducted multiple small trials in humans in the 1990s, trying to see if the drug had interesting effects on a variety of surrogate markers

Microdosing GLP-1s means starting at significantly lower doses than standard guidelinessometimes as low as 0.05 to 0.1 mg of semaglutide per week, compared to the usual starting dose of 0.25 mg

Interestingly, FXR agonists and inhibitors displayed beneficial effects on metabolic disorders, requiring more in-depth research

Dual GLP-1/GIP agonists like tirzepatide work even better and make sense when you want to maximize results or havent achieved your goals with GLP-1 alone