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GLP-1 medications improve glucose control and reduce systemic inflammation, which may reduce glycation stress on collagen
Pharmacokinetics of tirzepatide demonstrated dose proportionality over the wide dose range, with C max of 180 nM in individuals treated with one dose of 8 mg and a C max of 260 nM with 15 mg/week dose in the clinical study, exceeding the EC50 values for GIPR and GLP-1R activations by approximately 10,000-fold and 250-fold, respectively (63)
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A population-based matched case (220) controlled study found that the treatment of patient with T2MD with exenatide might increase the chance of hospitalization for acute pancreatitis
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