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Timing glutathione supplementation 23 hours after tirzepatide injection aligns peak antioxidant availability with the lipolysis surge that follows GLP-1 receptor activation

Introduction: Introduction: AOD-9604 is a synthetic peptide fragment of human growth hormone (hGH 177191) engineered to replicate hGHs fat-metabolism effects without altering IGF-1 or glucose levels. In preclinical research, it promoted lipolysis (fat breakdown) and reduced lipogenesis (fat storage) through receptor-independent mechanisms. AOD-9604 Fast Facts Class: Synthetic hGH fragment analog (Tyr-hGH 177191) Intended purpose: Stimulate fat metabolism while avoiding hGHs growth or glucose effects Mechanism: Increases fat oxidation, enhances lipolysis, suppresses lipogenesis Distinct from hGH: Does not activate the growth hormone receptor or raise IGF-1 Development stage: Completed Phase II trials

Memdouh S, Gavrilovi I, Ng K, Cowan D, Abbate V

Eli Lilly confirmed this in their Phase 1 pharmacokinetic study: no clinically relevant differences in total tirzepatide exposure between the abdomen, thigh, and upper arm