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Its also important to note that the participants in this study were not using weight loss medications

The average man or woman in the UK has a BMI over 27, so most people with heart disease are likely to benefit from adding semaglutide to their existing drugs, which already usually include aspirin, statins, blood pressure-lowering drugs, and other blood thinners." Professor Azeem Majeed, an expert in primary care and public health at Imperial College London, highlighted the potential for semaglutide as a preventive treatment: "The findings reinforce the use of semaglutide as a disease-modifying therapy for high-risk patients and not just as a weight-loss tool

This precision approach has consistently eliminated the perceived need for polypharmacy in weight loss

A substudy of this phase 1b trial showed also that retatrutide delays gastric emptying in humans, as measured by the acetaminophen test, though this effect lessens over time due to tachyphylaxis [44]