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Possible Interactions Metabolism and Absorption: Semaglutide is primarily processed by the kidneys and liver

It activates both GIP (glucose-dependent insulinotropic polypeptide) receptors and GLP-1 (glucagon-like peptide-1) receptors

Published online July 17, 2015 DOI: 8,658 View 41 Download 4 Web of Science 3 Crossref Abstract PDFPubReader ePub Background This study aimed to evaluate the effect of sitagliptin, an oral dipeptidyl peptidase-4 inhibitor, on insulin secretion and glucagon suppression in Korean subjects with type 2 diabetes mellitus