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The primary outcomes were the one-year cumulative incidence of acute coronary syndromes, coronary artery disease encounters, heart failure, stroke, and all-cause mortality, assessed both during treatment and after discontinuation

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Activation of the PKC pathway increases reactive oxygen species (ROS) production while promoting the expression of fibrotic factors, leading to glomerular dysfunction and fibrosis

Malignant peripheral nerve sheath tumours in neurofibromatosis type 1: MRI supports the diagnosis of malignant plexiform neurofibroma