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Prolonged UV exposure can induce matrix metalloproteinase-2 (MMP-2) and MMP-9 activation in basement membrane which can lead to collagen types 4 and 6 degradation and accumulation of more elastic fibers in melasma patients (Inomata et al., 2003)

Furthermore, single-nucleotide polymorphisms XBP1 in patients with vitiligo illuminate the importance of this pathway in the pathogenesis of vitiligo ( 5 Nrf2 Antioxidant response pathway Oxidative stress is considered as a major event in vitiligo pathogenesis (Figure 2A)

Clean the injection site with an alcohol wipe using a circular motion, moving outward from the centre, then allow the area to air dry completely (approximately 1015 seconds)

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