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[] A summary of all clinically proven natural products described in this study is provided in Table 1

Table of Contents The evolution of GLP-1 therapy into chronic treatment Gastrointestinal tolerability beyond three years Discontinuation trends and persistence patterns Strategies for maintaining long-term GLP-1 safety Clinical implications for chronic therapy The Evolution of GLP-1 Therapy Into Chronic Treatment In the early years of incretin-based therapy, clinicians often viewed GLP-1 receptor agonists as add-on treatments for patients with uncontrolled type 2 diabetes

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351 In the process of ferroptosis, cells are affected by oxidative stress and lipid peroxidation, resulting in the rupture of cell membranes and cell death, which is manifested mainly by the reduction in GPX4, the core enzyme of the antioxidant system (glutathione system), and the high expression of the lipid peroxidation marker 4-HNE