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More recently, the semaglutide STEP 3 study, which compared 2.4mg of once weekly semaglutide to placebo and included intensive behavioral therapy in both groups (hypocaloric diet plus exercise), reported 5% weight loss in 87% of those treated with semaglutide and 48% of those treated with placebo lost 5% body weight, and 10% weight loss in 75.3% treated with semaglutide and 27% treated with placebo (14)

Alkhatib M, Almasri N, Alshwayyat S, et al

J Pineal Res 56(1):97106 Parzych KR, Klionsky DJ (2014) An overview of autophagy: morphology, mechanism, and regulation

A 9% slower pace of biological aging based on the DunedinPACE epigenetic clock