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The term CHE was retained to avoid confusion from repeated nomenclature changes, to define OHE as West Haven grade II for clinical consistency, and because the distinction between MHE and grade I HE is difficult, and much of the existing literature applies to both [4]

Because 5-Amino-1MQ is a small molecule (not a peptide), peptide-related quality attributes such as amino-acid sequence, peptide content by sequence, TFA/acetate counterion ratios, or peptide-specific impurity profiles do not apply

In certain embodiments, any controlled release otic formulation or composition described herein alters (e.g

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