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Cerebral pharmacokinetics and microdialysis To confirm that a peptide actually reaches its cerebral target, microdialysis remains the reference tool: Principle : insertion of a semi-permeable membrane probe in a target region (hippocampus, frontal cortex)

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Although NADPH has multifunctional roles in regulating inflammation, particularly in myeloid cells that have been clearly defined in the past, it remains unclear how NADPH-dependent inflammatory and anti-inflammatory pathways are co-regulated in order to fine-tune the magnitude of an inflammatory response