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And while makers of the drugs have warned about side effects, which occur with other medications as well, experts note that long-term impacts still need to be explored

Interactions with concurrent medications: Levothyroxine : Separate magnesium supplements by at least 4 hours Bisphosphonates (e.g., alendronate): Magnesium can reduce absorption

Its influence on hormones that govern hunger and energy use is well-documented in clinical studies

A better and more defensible statement is this: retatrutide may create a better body-composition opportunity, but actual muscle retention or gain still depends on training, protein, recovery, and treatment design