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If your compound is 90% potent on day one, 50% on day three, and 10% by the end of the week, how can you possibly draw any valid conclusions from your study

Stopping is the safest option and avoids continued exposure to a compound without clear benefit

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Motor functioning was evaluated starting at 2 weeks post-surgery and testing was conducted on a biweekly basis using a walking track analysis where the rats were made to walk in a confined walkway lined with white paper and led into a dark shelter