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Extrapolating from cancer cells performing -oxidation under hyperoxic conditions in vitro to assuming they do so in vivo is akin to judging how fast a fish can run on land by measuring how swiftly it swims in water: the environment fundamentally alters the outcome, misrepresenting the true metabolic behavior of cancer cells within a living organism

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Yet even low-dose users reported darkening of existing moles and freckles in 73% of cases, a predictable consequence of MC1R activation but one that complicates melanoma surveillance