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Additionally, the lncRNA LIPE-AS1 is highly expressed in PCOS follicular fluid EVs and modulates steroid metabolism, granulosa cell proliferation, and apoptosis through the LIPE-AS1/miR-4306/LHCGR axis, contributing to poor oocyte quality and impaired embryo development (Yu et al., 2024)

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Summary In research contexts, DSIP (Delta Sleep-Inducing Peptide) is recognized for its potential benefits related to sleep regulation, neuroendocrine balance, stress adaptation, GABAergic signaling, and circadian rhythm alignment

In the US, the prevalence of melatonin use for sleep disorders among individuals 65 or older increased from 0.6% in 1999 to 2.1% in 2018, with a similar rise in use in UK