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Some of these were expected, like nausea, diarrhea, and low appetite

For pregnant or breastfeeding women, the safe daily intake of caffeine is halved from 400 mg to 200 mg, or about half a can

For people whose deficiency is caused by an absorption problem, injections are the more dependable option

Ketamine and psilocybin each produce a brief acute experience but set off a wave of synaptic growth afterward, ketamine through glutamate release and mTOR-dependent synapse formation and psilocybin through rapid, lasting growth of dendritic spines in the frontal cortex, both via BDNF signaling, which is why a single session can shift symptoms for weeks