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And previous studies in our laboratory have shown that conversion of Cys residues into Sec residues in GPx1 and GPx4 could result in dramatic loss of the catalytic activity 15,16

In murine models of NAFLD, nicotine exposure downregulated the expression of CDGSH iron-sulfur domain 3 (CISD3), leading to impaired mitochondrial function

No obvious toxicity was observed in any of the treatment groups, based on the average body weight, and the size and morphology of heart, liver, lung and kidney tissues, which did not differ significantly from that of control mice (Fig