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Specifically, enteroaggregative and enterotoxigenic Escherichia coli express heat-labile toxins 1 and 2, heat-stable toxins Sta, STb, and enteroaggregative heat-resistant toxin 1 (EAST1) that manipulate the osmotic state of the intestinal lumen by increasing chloride ion secretion from IECs

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Rybelsus, which was approved by the HSA in June 2021, has been indicated to be used for the treatment of adults with insufficiently controlled type 2 diabetes mellitus to improve glycaemic control as an adjunct to diet and exercise