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These versatile tools enable in-depth studies of cellular responses to 1D, 2D or 3D confinement [85, 148, 152, 159, 160], moderate or tight confinement [157, 158, 153,154,155, 160], short- or long-term confinement [153,154,155, 160], and confining pores or channels [148, 159, 153,154,155]

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Peripheral hyperinsulinemia can cause the levels and/or activities of the insulin receptor and/or post-receptor insulin signaling factors to be deficient in the brains of AD humans (Craft et al., 2012

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