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The copper chaperone ATOX1 is a particularly compelling target in this context

H., Weichhart, T., Heffeter, P., & Weckwerth, W

The enhanced production of superoxide would allow its reaction with nitric oxide (NO) within the mitochondria producing the reactive radical peroxynitrite (ONOO ), which can nitrate protein tyrosine residues and compromise their function [40] (Figure 1)

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