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This is sometimes referred to as a methyl trap, where folate becomes functionally unavailable without sufficient B12, and vice versa

Even Renue seems a little confused about this one, as its site suggests letting the powder dissolve under your tongue or mixing it into a beverage, which would result in a massive difference in efficacy

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In the early stages of the disease, bacterial metabolic products in dental plaque can activate host cells to release inflammatory mediators like interleukin-1, tumor necrosis factor-, further contributing to the release of oxygen free radicals and other types of oxidants ( To much production of oxidants results into oxidative damage to cells and matrix molecules in the gingival tissues, like lipid peroxidation, protein oxidation, and DNA damage, aggravating the severity and duration of the inflammatory response ( 2.3 Role of oxidative stress in the pathogenesis of periodontitis In the pathogenesis of periodontitis, oxidative stress is of great importance