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Insert the needle at a 90-degree angle perpendicular to your skin surface, which ensures the medication reaches the subcutaneous fat layer rather than muscle or dermis

doi: 10.3389/fphys.2025.1613917 Received 17 April 2025 Revised 30 September 2025 Accepted 07 October 2025 Published 20 November 2025 Corrected 27 November 2025 Volume 16 - 2025 Edited by Elena Di Pierro, IRCCS Ca Granda Foundation Maggiore Policlinico Hospital, Italy Reviewed by Tiago L Duarte, Universidade do Porto, Portugal Hans Bumler, Charit University Medicine Berlin, Germany Updates Copyright 2025 Rose, Moore, Eskew, Vanacore, Hartson, Province, Skaff and Smith