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The findings, published in JAMA Internal Medicine , come from a large randomized trial of nearly 9,650 adults who have both Type 2 diabetes and either cardiovascular disease or chronic kidney disease

However, the story is nuancedthe failure of the EVOKE trials testing oral Semaglutide in symptomatic Alzheimers Disease does not invalidate the strong epidemiological signal for GLP-1 agonists in dementia prevention, and SS-31s approval establishes important regulatory precedent for mitochondrial-targeted therapeutics