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Chemotherapy-Induced Peripheral Neuropathy (CIPN) Prevention: 3 RCTs (n=437, n=160, n=150) found no prophylactic benefit of acetyl-L-carnitine

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CJC-1295 (2mg/kg s.c.) produces GH peak at 2-3 hours, measurable hepatic IGF-1 mRNA induction at 4-6 hours, circulating IGF-1 elevation at 6-10 hours, and skeletal muscle protein synthesis augmentation (SUnSET) at 8-16 hours post-injection with sustained elevation for 3-5 days due to DAC half-life

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